Dennis McGonagle is Professor of Investigative Rheumatology in the Academic Unit for Musculoskeletal Diseases at the University of Leeds in Leeds, UK. He undertook preclinical training in medicine at University College Dublin, Republic of Ireland, and graduated in 1990, completing his clinical training and PhD in Leeds. He has been practising in rheumatology for many years.
Professor McGonagle is well known for his work with psoriatic arthritis (PsA) and has published several key articles relevant to understanding disease mechanisms in PsA including the enthesis-originating theory of disease with an associated secondary cytokine-mediated synovitis. His primary research interest is in developing imaging to assess stem-cell therapies for joint disease in order to develop novel therapies for osteoarthritis. His other major interest is the use of non-manipulated stem cells for arthritis therapy development.
Professor McGonagle has also described the synovio-entheseal complex concept and nail anchorage to the skeleton, and has developed an integrated biomechanical and immunology model for PsA and mechanistic disease classification papers. He has published over 360 peer-reviewed articles and has been involved in multiple clinical trials.
EM-18072 - Date of preparation: September 2019