Paul Klenerman is the Sidney Trulove Professor of Gastroenterology at the University of Oxford in the UK. He trained in medicine at the Universities of Cambridge, UK, and Oxford from 1982 to 1988 and completed a DPhil on HIV and T-cell escape in 1995. He received Wellcome Trust funding as Fellow from 1992 to 2015, and as Principal Investigator in 2015.
As a clinician scientist, Professor Klenerman’s main research interests are in the immunology of persistent infections, viral hepatitis, and mucosal defence. He has made consistent and major contributions to viral immunology with ground-breaking work on the hepatitis C virus (HCV). He was amongst the first to define the nature of the cellular immune responses to HCV and the features associated with immune protection and has translated this work into a potential vaccine platform for HCV and other viruses. He also has broad expertise in viral immunology, throwing light on the unique nature of the hepatic immune system, and how it can become dysregulated in chronic inflammatory disease, innate-like T cells such as MAIT cells enriched in liver and lung, and has worked extensively on “memory inflation” in the immune response.
Professor Klenerman has published widely in peer-reviewed journals including Nature, Science, and Gastroenterology. In May 2020, he contributed to the Oxford University “COVID Conversations” series of virtual events, talking about the Oxford Immunology Network’s research into the immune response to COVID-19, including their observations on the detection of neutralizing antibodies, antiviral T cells, and innate immune responses.
EM-35200 - Date of preparation: July 2020